Jesús M Salvador Lab Centro Nacional de Biotecnología (CNB)

T cell activation and differentiation in tumor suppression and autoimmunity

Jobs

1. POSTDOCTORAL POSITION IN IMMUNOLOGY & ONCOLOGY [Show][Hide]

The “Centro Nacional de Biotecnología” (CNB-CSIC), Madrid, Spain, has a postdoctoral position available in the laboratory of Dr. Jesús M. Salvador. We are dissecting the signaling pathways involved in development of autoimmunity and cancer using a multidisciplinary approach that combines mouse genetic, human epigenetic, biochemical, molecular biological and immunological techniques. Our project involves the generation and characterization of mouse models (knockout and knock-in), in vivo and in vitro analysis of T cell activation, proliferation, apoptosis and differentiation, and validation of these results in autoimmune disease and cancer patients.

  • SALARY: will be commensurate with experience
  • DURATION: 1-4 years renewable (2008-2012)
  • START DATE: Fall 2008
  • LOCATION: Dept. of Immunology & Oncology, Centro Nacional de Biotecnología (CNB-CSIC), Lab 411, C/ Darwin n 3, 28049 Madrid
  • QUALIFICATIONS:

    · Applicants must have two years postdoctoral research experience in the areas of immunology, protein biochemistry or molecular biology

    · An outstanding track-record of publications in high impact journals

SELECTED PUBLICATIONS AND PATENTS
  • Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, A. J. Jr., and Ashwell, J. D.:  Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.  Nat. Immunol. 6: 390-395, 2005.
  • López-Santalla, M., Salvador-Bernáldez, M., García, M.I., Eiró, N., Kremer, L., Roncal, F., Martínez-A, C., Salvador JM. The alternative p38 activation pathway regulates T cell receptor activation but not the stress response. J Exp Med 2007 (JEM ms#20070895).
  • Salvador, J. M., Mittelstadt, P. R.,  Belova, G. I., Fornace, A. J., Jr., and Ashwell, J. D.:  The autoimmune suppressor GADD45a inhibits the T cell alternative p38 activation pathway.  Nat. Immunol. 6: 396-402, 2005.
  • Salvador, J.M., Hollander, M.C., Nguyen, A., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., and Fornace, A. J. Jr.: Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 498-509, 2002.
PATENTS
  1. Patent application: P200702770 Entity: CSIC Priority date: November 2007
  2. Patent Number: WO2005/077983 PCT Application # PCT/US2005/003379
Download offer in pdf format (201 kb)

2. PREDOCTORAL POSITION IN IMMUNOLOGY & ONCOLOGY [Show][Hide]

The “Centro Nacional de Biotecnología” (CNB-CSIC), Madrid, Spain, has a postdoctoral position available in the laboratory of Dr. Jesús M. Salvador. We are dissecting the signaling pathways involved in development of autoimmunity and cancer using a multidisciplinary approach that combines mouse genetic, human epigenetic, biochemical, molecular biological and immunological techniques. Our project involves the generation and characterization of mouse models (knockout and knock-in), in vivo and in vitro analysis of T cell activation, proliferation, apoptosis and differentiation, and validation of these results in autoimmune disease and cancer patients.

  • DURATION: 1-4 years renewable (2008-2012)
  • START DATE: Fall 2008
  • LOCATION: Dept. of Immunology & Oncology, Centro Nacional de Biotecnología (CNB-CSIC), Lab 411, C/ Darwin n 3, 28049 Madrid
  • QUALIFICATIONS:

    · Applicants must have an excellent academic record and previous research experience

SELECTED PUBLICATIONS AND PATENTS
  • Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, A. J. Jr., and Ashwell, J. D.:  Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.  Nat. Immunol. 6: 390-395, 2005.
  • López-Santalla, M., Salvador-Bernáldez, M., García, M.I., Eiró, N., Kremer, L., Roncal, F., Martínez-A, C., Salvador JM. The alternative p38 activation pathway regulates T cell receptor activation but not the stress response. J Exp Med 2007 (JEM ms#20070895).
  • Salvador, J. M., Mittelstadt, P. R.,  Belova, G. I., Fornace, A. J., Jr., and Ashwell, J. D.:  The autoimmune suppressor GADD45a inhibits the T cell alternative p38 activation pathway.  Nat. Immunol. 6: 396-402, 2005.
  • Salvador, J.M., Hollander, M.C., Nguyen, A., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., and Fornace, A. J. Jr.: Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 498-509, 2002.
PATENTS
  1. Patent application: P200702770 Entity: CSIC Priority date: November 2007
  2. Patent Number: WO2005/077983 PCT Application # PCT/US2005/003379
Download offer in pdf format (200 kb)

3. LAB TECHNICIAN POSITION IN IMMUNOLOGY & ONCOLOGY [Show][Hide]

The “Centro Nacional de Biotecnología” (CNB-CSIC), Madrid, Spain, has a postdoctoral position available in the laboratory of Dr. Jesús M. Salvador. We are dissecting the signaling pathways involved in development of autoimmunity and cancer using a multidisciplinary approach that combines mouse genetic, human epigenetic, biochemical, molecular biological and immunological techniques. Our project involves the generation and characterization of mouse models (knockout and knock-in), in vivo and in vitro analysis of T cell activation, proliferation, apoptosis and differentiation, and validation of these results in autoimmune disease and cancer patients.

  • DURATION: 1-4 years renewable (2008-2012)
  • START DATE: Spring 2008
  • LOCATION: Dept. of Immunology & Oncology, Centro Nacional de Biotecnología (CNB-CSIC), Lab 411, C/ Darwin n 3, 28049 Madrid
  • QUALIFICATIONS:

    · Applicants must have experience in molecular bioloy and immunology. Experience in the characterization of mouse models will be highly valued. Basic computer skills essential

SELECTED PUBLICATIONS
  • Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, A. J. Jr., and Ashwell, J. D.:  Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.  Nat. Immunol. 6: 390-395, 2005.
  • López-Santalla, M., Salvador-Bernáldez, M., García, M.I., Eiró, N., Kremer, L., Roncal, F., Martínez-A, C., Salvador JM. The alternative p38 activation pathway regulates T cell receptor activation but not the stress response. J Exp Med 2007 (JEM ms#20070895).
  • Salvador, J. M., Mittelstadt, P. R.,  Belova, G. I., Fornace, A. J., Jr., and Ashwell, J. D.:  The autoimmune suppressor GADD45a inhibits the T cell alternative p38 activation pathway.  Nat. Immunol. 6: 396-402, 2005.
  • Salvador, J.M., Hollander, M.C., Nguyen, A., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., and Fornace, A. J. Jr.: Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 498-509, 2002.
Download offer in pdf format (198 kb)